
Esse jogo foi desenvolvido no mesmo estilo de seu antecessor,Open World, onde o jogador pode explorar livremente as ilhas de Manhattan, Roosevelt e a Governor’s island (sendo que essa última só esta disponível na missão “Scorpion part 1”) e a novidade é que agora pode-se explorar todo o sistema do metrô de Nova York, ATENÇÃO essa é a jogabilidade das versões de PC, Playstation 3 e Xbox 360 (outras versões tem jagabilidades diferente). O jogador controla o herói Homem-Aranha, que deve lutar contra gangues, facções e vilões da cidade para mantê-la em equilíbrio, muitas vezes contando com a ajuda da polícia local.

Spider-Man 3 é um jogo de ação em terceira pessoa, criado pela Treyarch (versão para PS3 e Xbox 360) e distribuido pela Activision, lançado em 4 de Maio de 2007 para diversas plataformas. É baseado no terceiro filme do Homem-Aranha, dirigido por Sam Raimi. As versões de PS2, GBA, Wii, PSP e Nitendo DS foram desenvolvidas pela Vicarious visions, quanto a de PC é a mesma da Treyarch (sendo que sua jogabilidade foi convertida pela Benoox).

O jogo apresenta todos os vilões do filme, além de muitos outros inimigos clássicos do herói, que já apareceram nos quadrinhos, como o Lagarto, Rei do Crime, Escorpião e uma imensa variedade de NPCs, que constituem a população de Manhattan.
O local é baseado na ilha de Manhattan, em Nova Iorque, apresentando muitas semelhanças entre a realidade, como, por exemplo, o Central Park e o Edifício Empire State e uma imensidão de veículos, que devido a esse fator, podem ser notados congestionamentos nas principais avenidas. No entanto, a produção de prédios sem detalhes e profundidade diminui a jogabilidade do game.
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